Nels and Vincent provide insights into the mystery of mouse mummies on the summits of >6000 m Andean volcanoes, including whether they were living there and if so why?
Hosts: Nels Elde and Vincent Racaniello
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•Mystery of mouse mummies (bioRxiv)
Nels – Zoonomia
Vincent – SeaPhages
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Nels and Vincent discuss the observation that cells on a boundary of a solid tumor have higher growth rates compared to those in the center and how to model this difference using genome sequencing data.
Hosts: Nels Elde and Vincent Racaniello
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•Evolutionary models of solid tumor growth (Nat Ecol Evol)
Nels – TWiV 1000
Vincent – The dream of wiping out polio might need a rethink
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Nels and Vincent review a study of the dogs of Chernobyl which reveals that genetically distinct populations with different amounts of western breed contributions to their genomes, the first step in assessing the effects of exposure to long-term ionizing radiation.
Hosts: Nels Elde and Vincent Racaniello
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•The dogs of Chernobyl (Science Adv)
•What the dogs of Chernobyl can teach us (Stat)
•Letters read on TWiEVO 88
Nels – Hellbent documentary and Insufficient evidence for natural selection associated with the Black Death
Vincent – BioRender
Walter – Oded Rechavi and interview
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Nathan joins Nels and Vincent to discuss his approach to understanding how species adopt novel traits to overcome challenges, and its application to identifying coding and noncoding sequence changes that underlie mammalian hairlessness.
Hosts: Nels Elde and Vincent Racaniello
Guest: Nathan Clark
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•Gene loss in marine mammals (TWiEVO 34)
•Gene change underlying mammalian hair loss (eLife)
•Letters read on TWiEVO 87
Nels – Local news coverage of Amanda, Maria, and Nathan’s paper
Vincent – Discovering Retroviruses by Anna Marie Skalka
Nathan – Genomics of Secondarily Temperate Adaptation in the Only Non-Antarctic Icefish
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Nels and Vincent discuss how evolution of changes in stop codon assignment might occur, and a novel mechanism for altering the meaning of translation stop codons discovered in a trypanosomatid with the apropos name, Blastocrithidia nonstop.
Hosts: Nels Elde and Vincent Racaniello
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•Novel stop codon reassignment mechanisms (Nature)
Nels – Protein Synthesis: An epic on the cellular level
Vincent – Widespread stop-codon recoding in bacteriophages may regulate translation of lytic genes discussed on TWiM 277
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