Simon and Heather join TWiEVO to discuss their analysis of the evolutionary history of ACE2 usage by coronaviruses in the Sarbecovirus genus.
Hosts: Nels Elde and Vincent Racaniello
Guests: Simon Anthony and Heather Wells
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Links for this episode
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Jessie, Allie and Tyler join Nels and Vincent to describe their work on deep mutational scanning of the SARS-CoV-2 receptor binding domain.
Hosts: Nels Elde and Vincent Racaniello
Guests: Jesse Bloom, Allie Greaney, and Tyler Starr
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Links for this episode
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent continue their discussion of SARS-CoV-2 evolution, including understanding recurrent mutations in the viral genome, and the potential for re-emergence of the virus from an animal reservoir.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels - The Cell in Evolution
Vincent - Visual Science
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent continue their discussion of SARS-CoV-2 evolution, with a report that the coronavirus proofreading enzyme stimulates RNA recombination, and debunking the conclusion that a change in the viral spike glycoprotein is associated with increased human to human transmission.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels - In Memoriam: Gordon Lark
Vincent - John Oliver Discussion of Antibody Tests
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, including function of the furin cleavage site, whether Vervet cells are an informative system, another bat isolate, and a nomenclature to assist genomic epidemiology.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels - EvoEco seminars
Vincent - Coronavirus book for children
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, focusing on what the genome sequences tell us about the virus.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels - Science Mill Explorer Zone
Vincent - COVID-19 treatment and therapy tracker
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent examine SARS-CoV-2 from an evolutionary viewpoint, examining what the spike glycoprotein sequence informs us about the origin of the virus.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels - Alejandro Sanchez TED Talk
Vincent - WHO SARS-CoV-2 Sitrep
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent dive deep into evolution and consider how new proteins emerged billions of years ago, when there were no other proteins to serve as starting material.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels - Universal principled review
Vincent - Hostile Planet by National Geographic
Courtney - Nightwish Endless Forms Most Beautiful and Shudder Before The Beautiful
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent discuss signatures of sex chromosome evolution revealed by assembly of a young vertebrate Y chromosome from 3-spined stickleback fish.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels - Genome from a 5,700-Year-Old Wad of Chewed Gum
Vincent - NJ Sea-Level Rise Reports
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Rich joins Nels and Vincent for a debriefing on the 4th Ringberg Symposium on Giant Virus Biology in Tegernsee, Germany.
Hosts: Nels Elde and Vincent Racaniello
Guest: Rich Condit
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Rich - Flightradar24
Nels - Deutsches Museum Munich
Vincent - Diversify Microbiology
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent reveal a new choanoflagellate that forms multicellular cup shaped colonies that respond to light to alternate between feeding and swimming behavior.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels - How to write a great science paper by Cormac McCarthy
Vincent - Natural Selection Store
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent trace the origins of Saccharomyces cerevisiae strains used to make beer, and find that ales and lagers are made with yeasts that were derived from those used to make European grape wine and Asian rice wine.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels - Population fluctuations in 10 biggest cities
Vincent - 1.7 million year old rhino tooth (original Nature paper)
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent analyze the genomes of canine transmissible tumors to provide insight into the worldwide spread of the disease from its origin in a single dog 4000-8500 years ago, and its diversity, mutation, and evolution.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels - Vasa Museum in Stockholm
Vincent - Nobel Museum in Stockholm
Irene - @EndlessFormsand #PlantScienceFascinatesMe #plantsday
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
At ASM Microbe in San Francisco, Nels and Vincent meet up with Talia Karasov who reveals that in contrast to agriculture, wild plants are colonized by multiple lineages of pathogenic bacteria.
Hosts: Nels Elde and Vincent Racaniello
Guest: Talia Karasov
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
At ASM Microbe in San Francisco, Nels and Vincent meet up with Paul Turner to talk about evolutionary considerations in using bacteriophages to treat infections with antibiotic-resistant bacteria.
Hosts: Nels Elde and Vincent Racaniello
Guest: Paul Taylor
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels- Science Glass
Vincent- Phage therapy for disseminated Mycobacterial infection
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Dustin Rubinstein joins Nels and Vincent to discuss coevolution of genome architecture and social behavior, and studying social transitions in sponge-dwelling snapping shrimp.
Hosts: Nels Elde and Vincent Racaniello
Guest: Dustin Rubinstein
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Dustin- Genesis: The Deep Origin of Societies 1 by E.O. Wilson, and The Human Swarm by Mark O. Moffett
Nels- For Love of Insects by Thomas Eisner
Vincent- Quacks blamed for Pakistan HIV-1 outbreak
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent review the contribution of multiple Denisovan lineages to the modern Papuan genome.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels- Sydney Brenner - What Genomes Can Tell Us About the Past
Vincent- Scientific Communication in a Post-Truth Society
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent explore the evolution of new protein-coding genes de novo from nocoding DNA sequences, using the antifreeze protein of northern codfish as a model.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels- Science at Sundance reviews
Vincent- The Rise and Fall of Scientific Authority
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent move back to reproductive isolation - this time, pre-zygotic, in the charismatic orchid bee where the males make chemically distinct perfumes to attract mates of the same species.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels- Nature Zen: Orchid Bees Are Shiny
Vincent- What You Believe About Science Denial May Be All Wrong
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent look at the intracellular bacteria Legionella from an evolutionary perspective: the role of gene acquisition and reshuffling from plants, animals, fungi, and archaea in the emergence of human pathogens.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels - Science in Film (twitter)
Vincent - Lunar Eclipse 101
Nels and Vincent reveal a highly conserved protein that acts as an evolvability factor, increasing mutation and the ability of bacteria to become resistant to antibiotics.
Hosts: Nels Elde and Vincent Racaniello
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels- Science/nature illustrator/artist Rachel Ignotofsky (website, Etsy shop)
Vincent- Life Ascending by Nick Lane
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
David Quammen joins Nels and Vincent to talk about his new book, A Tangled Tree, including evolutionary trees, Carl Woese, Lynn Margulis, horizontal gene transfer, and much more.
Hosts: Nels Elde and Vincent Racaniello
Guest: David Quammen
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Mia joins Nels and Vincent to unravel their finding that the transposons that maintain the ends of chromosomes in Drosophilahave evolved in conflict with the genome.
Hosts: Nels Elde and Vincent Racaniello
Guest: Mia Levine
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiEVO
Nels - Cinema Science podcast
Vincent - Mastodon bones unearthed (Instagram, Grand Rapids News)
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent reveal that female-specific DNA associated with sex in strawberries has repeatedly changed its genomic location, possibly linking new genes with sex.
Hosts: Nels Elde and Vincent Racaniello
Become a patron of TWiEVO
Nels - New snailfish and Cloned crayfish
Vincent - A PhD Lab Coat Ceremony
Steve - Diversity in simple blobs
Justin - On Growth and Forms by D'Arcy Wentworth Thompson
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
Nels and Vincent discuss how the loss of an enzyme in marine mammals millions of years ago now makes them at risk for neurotoxicity caused by human-made organophosphorous pesticides.
Hosts: Nels Elde and Vincent Racaniello
Become a patron of TWiEVO
Hey farmer farmer put away the chlor-pyri-fus
I don’t care about spots on my apples
Leave me the manatee and walruses
Nels - New dinosaur discovered in Utah
Vincent -The Song of the Dodo by David Quammen
Music on TWiEVO is performed by Trampled by Turtles
Send your evolution questions and comments to twievo@microbe.tv
